PABA and its esters were among the earliest UV absorbers to be introduced in the United States, and sensitization was documented as early as It may stain clothing, and it has been associated with a number of adverse reactions, including allergic and photoallergic contact dermatitis. These derivatives have become more popular for use in sunscreen products because of a higher compatibility with other cosmetic vehicles and a decreased propensity for staining. Reports of photoallergy to PABA and its ester counterparts, however, have led to sllergy near removal from sunscreen manufacturing. Today, PABA products are used only rarely in sunscreen formulations.
The dibenzoylmethanes possess a broad absorption spectrum with maximal absorption in the UVA range, [ 44 ] and their use has increased as a result of reported sensitivities to benzophenones and PABA products. Both contact allergy and photocontact allergy to dibenzoylmethanes have been reported. In Schauder and Ippen's study, Reports of allergies to 4-tert-butyl-4'-methoxy-dibenzoylmethane exist, but several of these allergies may have resulted from cross-reactivity caused by prior exposure to the isopropyl derivative Eusolex Avobenzone is often combined with UVB-blocking agents in commercial sunscreens for broad-spectrum protection, and physicians must be aware of this when patch-testing patients with the patients' personal sunscreen products.
Anthranilates are derivatives of ortho-aminobenzoic acid. Xllergy absorb UVA radiation of wavelengths between and nm. They are often combined with UVB absorbers to give broad-spectrum aymptoms. Unlike their para-amino counterparts, anthranilates are not common sensitizers. Anthranilates are currently part of the sunscreen series recommended for photopatch testing by the NACDG.
Most of the 37 patients who demonstrated allergy or photoallergy to methylbenzylidene camphor in a study by Schauder and Ippen demonstrated concomitant photosensitization to isopropyl dibenzoylmethane. Octyl triazone 2,4,6-trianalino-[p-carbo-2'-ethylhexyl-1'oxy] 1,3,5 triazine is a UVB absorber unrelated to any of the aforementioned chemical sunscreens.
It is highly polar and completely insoluble in water. A literature search found one case report of photoallergy to this compound. Sommer and colleagues described a year-old woman with an erythematous bullous eruption on sun-exposed areas after sunscreen use.35) Octyl Methoxycinnamate, Octyl Salicylate, Oxybenzone, and Padimate O 36) Octyl Methoxycinnamate, Octyl Salicylate, Oxybenzone, Padimate O, and Titanium Dioxide † 37) Octyl Methoxycinnamate, Octyl Salicylate, Oxybenzone, Phenylbenzimidazole, and Titanium Dioxide † 38) Octyl Methoxycinnamate, Octyl Salicylate, Oxybenzone, and Titanium Dioxide. Common sunscreens I'm allergic to on my lips are: Octinoxate Octisalate Octocrylene Oxybenzone Padimate O So I'm not sure how I should protect my lips. Right now I only use Aquaphor because it's cheap and has the best results on my lips, but that won't protect them from the sun. Nov 02, · However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness.
Both products were found in her personal sunscreen. Patch-test concentrations were not reported.
Allergy to this chemical agent is rare. On routine photopatch testing of patients with suspected photosensitivity in Sweden, Berne and Ros found two patients with photocontact allergy to this chemical.
Authors and Disclosures
Octocrylene 2-ethylhexylcyano-3,3-diphenylacrylate is a UVB chemical photoprotectant that has been used in sunscreens for less than a decade. Two patients with photoallergy symptms this unique agent were reported padimate Carotte-Lefebvre and colleagues in Other chemical sunscreen agents incorporated into commercial products include etocrilene ethyl 2-cyano-3,3-diphenylacrylatedrometrizole trisiloxane, bisethylhexyloxyphenol methoxyphenol triazine, drometrizole 2- zip benzotriazoledioctyl butamido triazone, and terephthalylidene dicamphor sulfonic acid Mexoryl SX, L'Oreal, Aulnay Sous Bois, France.
A literature search revealed no cases of symptoms or photoallergy to these products, nor were any allergy concentrations referenced.
Some of the first physical UV blockers used in the United States were opaque formulations that scattered or reflected UV radiation. Recently, however, microsized forms have become available.
Allergy to PABA | DermNet NZ
Titanium dioxide and zinc oxide are the most common physical UV blockers used today. These agents have not been reported to cause contact dermatitis or photoallergy. You've successfully added to your alerts. You will receive email when new content is published.
Sunscreen Allergy: Epidemiology, Characteristics, & Allergens
Specialty: Multispecialty. Log In. Sign Up It's Free! Register Log In. No Results. If you log out, you will be required to enter your username and password the next time you visit. Log out Cancel. In This Article. Next Section. Click the topic below to receive emails when new articles are available.
What to Read Next on Medscape. Recommended Reading overview. Drugs Related to null telaprevir. Drug Interaction Checker. Your Name:.
Padimate O (Bulk) : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Your Email: Send me a copy. Recipient's Email:. Optional Message. This website also contains material copyrighted by 3rd parties.
Allergic contact dermatitis reactions may occur when these agents are used in PABA sensitive individuals. Benzocaine is the most notorious sensitizer. PABA sensitivity produces classic allergic contact dermatitis as well as photocontact dermatitis.
In PABA allergic individuals, sunscreens containing PABA or its esters can cause a burning or stinging sensation particularly if the product is alcohol-based.
However, burning and stinging may also sometimes occur as an irritant reaction in people with sensitive skineven when not actually allergic to Apdimate.
Occasionally injection of PABA-derived local anaesthetics zio allergic individuals may cause swelling of the oral mucosa stomatitis at the site of the injection. Rarely, more severe reactions such as generalised urticaria or anaphylaxis may result. PABA allergy is diagnosed by performing special allergy tests, i. Read product labels and avoid products that contain PABA or any of its alternative names.Padimate O Drug Information, Professional
symptoms Avoid related substances that you may also be allergic to. This padimate sunscreen products containing PABA esters, paraphenylenediamine PPD a,lergy found in permanent hair dyes, allergyand azo dyes. Ask your pharmacist for advice and a suitable alternative. Alert your doctor and dentist zip the fact that you have an allergy to PABA. Your dermatologist may have further specific advice, particularly if you are highly sensitive. See smartphone apps to check your skin.