Adults and children 12 years of age and over: Take one mg tablet with water once a day; do not take more than 1 tablet in 24 hours. Ask a doctor before use if you have kidney disease. Your doctor should determine if you need a different dose. Stop use and ask a doctor if an allergic reaction to this product occurs. Seek medical help right away.
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Allegra-D 24 Hour Dosage Generic name: fexofenadine hydrochloride mg, pseudoephedrine hydrochloride mg Dosage form: tablet, film coated See also: Allegra D 12 hour tablet, extended release Medically reviewed dose Drugs. Drug Class. Upper respiratory combinations. Related Drugs. Allegra-D 24 Hour Images. Subscribe to our newsletters.
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Pseudoephedrine hydrochloride occurs as fine, white to off-white crystals or powder, having a faint characteristic odor. It is hur soluble in water, freely soluble in allergy, and sparingly soluble in chloroform. The tablet has AV printed on one side in black ink. In a placebo-controlled clinical study in the United States, which included subjects with seasonal allergic rhinitis aged 12 allergy and older receiving fexofenadine hydrochloride tablets at doses of or mg once daily, adverse events were similar in fexofenadine hydrochloride and placebo-treated subjects.
In rare cases, rashurticariapruritus and hypersensitivity reactions with manifestations hour as angioedemachest tightness, dyspneaflushing and systemic anaphylaxis have been reported. Pseudoephedrine hydrochloride may cause mild CNS stimulation in dd patients.
Nervousness, excitability, restlessness, dizziness, weakness, or insomnia may occur. Headache, drowsiness, tachycardiapalpitation, pressor activity, cardiac arrhythmias and ischemic colitis have been reported. Sympathomimetic drugs have also been associated with other untoward effects such as fear, anxiety, tenseness, tremorhallucinations, seizures, pallor, respiratory difficulty, dysuriaand cardiovascular collapse. Fexofenadine hydrochloride and pseudoephedrine hydrochloride do not influence allergyy pharmacokinetics of each other when administered concomitantly.
Fexofenadine has been allergg to exhibit minimal ca. However, co-administration of fexofenadine hydrochloride with either ketoconazole or erythromycin alleggy dose increased plasma concentrations of fexofenadine.
Fexofenadine had no effect on the pharmacokinetics of either erythromycin or ketoconazole. No differences in adverse events or QTc interval were observed when subjects were administered fexofenadine hydrochloride alone or in combination with either x or ketoconazole. The findings of these studies are summarized in the following table:.
The changes in plasma levels were within the range of plasma levels achieved in adequate and well-controlled clinical trials. The mechanism of these interactions has been evaluated in in vitro, hour situ, and in dose animal models.
What is Allegra 24 Hour Allergy?
These studies indicate that ketoconazole or erythromycin co-administration enhances fexofenadine gastrointestinal absorption. This observed increase in the bioavailability hour fexofenadine may be due to transport-related effects, such as p-glycoprotein.
In vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion.
Concomitant allergy with antihypertensive drugs which dose with sympathetic activity e. Qllergy ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis.May 01, · Allegra 24 Hour Allergy is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Allegra 24 Hour Allergy is used to treat the symptoms of seasonal allergies in adults and children.. Allegra 24 Hour Allergy is also used to treat skin itching and hives caused by a condition called / Feb 25, · The recommended dose of ALLEGRA-D 24 HOUR (fexofenadine hcl and pseudoephendrine hcl ) Extended-Release Tablets is one tablet once daily administered on an empty stomach with water for adults and children 12 years of age and older. The recommended dose of ALLEGRA-D 24 HOUR Extended-Release Tablets is one tablet once daily administered on an empty stomach with water for adults and children 12 years of age and older. ALLEGRA-D 24 HOUR tablets should generally be avoided in patients with renal insufficiency. ALLEGRA-D 24 HOUR must be swallowed whole and never crushed or chewed/
Fruit juices such as grapefruit, alelrgy and apple may reduce the bioavailability and exposure of fexofenadine. This is based on the results from 3 clinical studies using histamine induced skin wheals and flares coupled with population pharmacokinetic analysis. The size of wheal and flare were significantly larger when fexofenadine hydrochloride was administered with either grapefruit or orange juices compared to water.
Allegra 24 Hour Allergy Uses, Side Effects & Warnings - fzbv.fastpitch.pro
Based on the literature reports, the same effects may be extrapolated to other fruit juices such as apple juice. The clinical significance of these observations is unknown.
Sympathomimetic amines may produce central nervous system stimulation with convulsions or cardiovascular collapse with accompanying hypotension. There are no animal or in vitro studies on the combination product fexofenadine hydrochloride and pseudoephedrine hydrochloride to evaluate allergy, mutagenesisor impairment of fertility. The carcinogenic potential and reproductive toxicity of fexofenadine hydrochloride were assessed using terfenadine studies with adequate fexofenadine exposure area-under-the plasma concentration versus time curve [AUC].
Teratogenic Effects: Category C. Hour combination of terfenadine and pseudoephedrine hydrochloride in a ratio of dose weight was studied in rats and rabbits.
There are no adequate and well-controlled studies in pregnant women.
Nonteratogenic Effects. It is not known if fexofenadine is excreted in human milk. Because many drugs are excreted in human allergy, caution should be used when fexofenadine hydrochloride is administered to a nursing woman. Pseudoephedrine hydrochloride administered alone distributes into breast milk of lactating human females.
Pseudoephedrine concentrations in milk are consistently higher than those in plasma. The fraction of a pseudoephedrine dose excreted in milk is estimated to be 0. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Clinical studies of ALLEGRA-D 24 HOUR fexofenadine hcl and pseudoephendrine hcl did not include sufficient numbers of subjects aged 65 and older to determine whether they respond differently dose younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, although the elderly are more likely to have adverse reactions to sympathomimetic amines. The pseudoephedrine component of ALLEGRA-D 24 HOUR fexofenadine hcl and pseudoephendrine hcl is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.
Because elderly patients are more likely to have decreased renal function, it may be useful to monitor renal function. Most reports of fexofenadine hydrochloride overdose contain limited information. However, dizziness, drowsiness, and dry mouth have been reported. For the pseudoephedrine hydrochloride component of ALLEGRA-D 24 HOUR fexofenadine hcl and dose hclinformation on acute overdose is limited to the marketing history of pseudoephedrine hydrochloride.
Single doses of fexofenadine hydrochloride up to mg 6 healthy volunteers at this dose leveland doses hour to mg twice daily for one month 3 healthy volunteers at this dose levelwere administered without the development of clinically significant adverse events.
In large doses, sympathomimetics may give rise to giddiness, headache, nauseavomiting, sweatingallergy, tachycardiaprecordial pain, palpitations hour, difficulty in micturitionmuscular weakness and tenseness, anxietyrestlessness, and insomnia. Many patients can present a toxic psychosis with delusions and hallucinations. Some may develop cardiac arrhythmias, circulatory collapse, convulsions, comaand respiratory failure.
In the event of overdose, consider standard measures to remove any unabsorbed drug. Symptomatic and supportive treatment is recommended.
Allegra-D 24 Hour Dosage Guide - fzbv.fastpitch.pro
Following administration of terfenadine, hemodialysis did not effectively remove fexofenadine, the major active metabolite of terfenadine, from blood up to 1.
The effect of hemodialysis on the removal of pseudoephedrine is unknown. It is also contraindicated in patients with severe hypertensionor severe coronary artery disease, and in those who have shown idiosyncrasy to its components, to adrenergic agents, or dose other drugs of similar chemical structures. Manifestations of patient idiosyncrasy to adrenergic agents include: insomnia, dizziness, weakness, tremoror arrhythmias.
Fexofenadine hydrochloride, the major hour metabolite of terfenadine, is an antihistamine with selective peripheral H 1 -receptor antagonist activity. Fexofenadine hydrochloride inhibited antigen -induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats. In laboratory animals, no anticholinergic or alpha 1 -adrenergic-receptor blocking effects were observed. Moreover, no allergy or other central nervous system effects were observed.
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Radiolabeled tissue distribution dosw in rats indicated that fexofenadine does not cross the blood-brain barrier. Pseudoephedrine hydrochloride is an orally active sympathomimetic amine and exerts a decongestant action on the nasal mucosa. Pseudoephedrine hydrochloride is recognized as an effective agent for the relief of nasal congestion due to allergic rhinitis.